Horny Goat Weed Extract

Horny Goat Weed Extract

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MIGU supplied Horny Goat Weed Extract Icariin 10% 50% 60% 98% and etc with analysis meets the EP, USP, JP, CP.....

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Horny Goat Weed Extract ( Epimedium Extract ) Icariin 10% 50% 60% 98%  offered by 
16 years experienced cGMP manufacturer with warehosues in China 

Latin Name: Epimedium sagittatum
Material Original:GanSu, China
Extracted Part: Branches and leaves
Supported Purity: Icariin 5% 10% 20% 30% 40% 50% 60% 98%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

History of Epimedium (Horny Goat Weed Extract ) Icariin:

Epimedium (Horny Goat Weed) has 2,000 years to used as a sex-enhancer and Man’s Health in China.Many
cultures and clinical testing report that epimedium supports libido, erectile function,and helps to relieve menopausal
discomfort.One ingredient of it is reported to support erectile problems,for men and women with low libido,and
for women undergoing menopause. Horny Goat Weed(epimedium)is comprised of several species of epimedium,
a leafy plant which grow in the wild,most abundantly at higher altitudes like QingLing mountains in China.

Epimedium is used as an herbal  aphrodisiac because it increases blood flow to the genital area. Referred
to as Yin-Yang Huo in China,where it originates,Horny Goat Weed also  lowers  blood  pressure by dilating
capillaries  and  blood  vessels  while  slowing the adrenal production that can prevent blood from reaching the
genitalia. Epimedium is grown as an ornamental herb in  Asia and the Mediterranean region, and various species
are  used for  medicinal  purposes,including Epimedium sagittatum, Epimedium brevicornum, Epimedium
wushanense, Epimedium koreanum, and Epimedium pubescens.

How does the Epimedium (Horny Goat Weed Extract) Actions in pharmacological

Epimedium  herb has  flavonoids  such as icariin,  epimedin A,  epimedin B, epimedin C and  baohuoside Iicariin
along with  prenylated  flavonol  glycosides  sagittasine A-C,  acylated  flavonol  glycosides such  as  kaempferol
together with flavonolignans,2-phenoxychromones, a lignan,and aromatic acid derivatives.Some of these be of
compounds,  particularly  icariin ,promote endothelial nitric  oxide-dependent relaxation of blood vessels and
hence can help for the treatment of erectile function and impotence.

Therapeutic  effects  of Horny  Goat  Weed  include  invigorating  kidney  function, reversing  male  and female
infertility, strengthen  tendons  and  bones, decreasing  muscular spasm, relieving  coughs and  lowering blood
pressure. The  herb has  also been  used for  liver and  kidney toning and has improved the life of chronic renal
failure patients in a Chinese  study.


Horny Goat Weed Extract Specification Supplied 

MIGU owned independent workshop which mainly produce the icariin ingredients for epimedium
extract. All of the material getthering from GanSu province with wild material. We owned experience extracting
engineers for guarantee our high quality ingredients of icarrin. Now listed some of welcomed ingredients
as below for your reference. If you have any other customizing required, please email us freely.

 

 

 

 

 

 

 

 

 

 

 

 

Indications and Uses of Horny Goat Weed Extract Icariin

Horny goat weed is used for weak back and knees .joint pain.osteoarthritis,mental and physical fatigue,memory 
loss.high blood pressure,heart disease,bronchitis,liver disease, HIV/AIDS,polio,a blood disorder called chronic
leucopenia, viral infections of the heart, bone loss after menopause, weak bones (osteoporosis), and as a tonic
Some  men use  horny  goat weed  for  sexual performance  problems  including  erectile dysfunction (ED)  and
involuntary ejaculation. It is also used to arouse sexual desire

How does it work for Horny Goat Weed Extract 

Horny goat weed contains chemicals which might help increase  blood flow and improve sexual function. It also
contains phytoestrogens, chemicals that  act somewhat  like the female hormone estrogen, that  might reduce
bone loss in postmenopausal women.

 

A : Function of Erectile Dysfunction

Study show: Oral treatment with icariin (>98.6% purity ) for 4 weeks potentially improves erectile function .This
effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats.These
results suggest that icariin may have a therapeutic effect on erectile dysfunction(Asian J Androl 2005 Dec;7:381
-388)

B:Male Sexual Enhancement   

Growing  body of  research  shows that  isolated  Icariin  inhibits  the  enzyme  phosphodiesterase-5(PDE-5) and
significantly increase nitric oxide synthase,helping to improve erectile function in multiple model.Studies also
indicate that isolated Icariin increase circulating testoserone levels . However, unlike prescription medications
epimedium doesn’t  work in an hour or two.It normally takes several days for the sexual benefits  to be noticed

C:Immune Enhancement  

Studies suggest that isolated Icariin plays  role in immune enhancement via the regulation of various hormone
pathways.Specifically,research indicates estrogenictype activity in female breast cell lines, inhibiting property
in male prostate  cell lines ,as well as testosterone mimetic properties

D:Anti-Depressant,Antioxidant 

Recent  finding point to  animportant role  for isolated  Icariin in  the mitigation  of symptoms  associated with
depression . In particular, isolated Icariin has been shown to reduce know stress -induced triggers,such as brain
monoamine oxidase  A&B, serum corticotropin -releasing factor, and cortisol. Studies show that, from a kinetic

standpoint , isolated Icarrin is a far more effective antioxidant than know antioxidants such as vitamins E and C
Most important,however, isolated Icariin is demonstrated to significantly increase naturally -occuriing levels of
super antioxidant,SOD( superoxide sismutase).

Scientific Study of Horny Goat Weed Extract

Human studies
As 2014, we could only find one human study with epimedium herb. Effect of Epimedium sagittatum on quality
of life and cellular immunity in patients of hemodialysis maintenanceZhongguo ZhongXiYi Jie He Za Zhi.1995.In
present study, we  investigated the  therapeutic effect of  Epimedium  Sagittatum on patients of hemodialysis
maintenance.22 cases of regular hemodialytic patients were treated with this herb in the form of decoction.12
patients with hemodialysis were served as controls.It was found that Epimedium plant had sexual potentiation
effect  and  improved the  quality of  life in  the  patients of  chronic  renal  failure  with  regular  hemodialysis
Interleukin 2 (I-L2) activity of peripheral  blood monocytes stimulated by PHA was increased significantly in the
patients treated with the herbal preparation.It is suggested that this Chinese medicine had therapeutic effect
on sexual disorder & immunologic inadequacy in the patients of chronic  renal failure undergoing  hemodialysis

Drug interactions
It is possible that  epimedium could interact with  prescription  stimulant drugs, anti-depressants Zoloft, Paxil,
Prozac, heart medications blood pressure medications,and erectile dysfunction meds such as Viagra,Cialis,and
Levitra. Caution is advised when mixing herbal remedies with prescription medications.

Animal studies
OsteoporosisPrevention of bone loss by aqueou extract of Epimedii sagittatum in an ovariectomized rat model
of osteoporosis.ZhongXiYiJieHeXueBao.2006; Department of Pharmacy,Yueyang Hospital of Chinese Integrative
Medicine,Shanghai University of TraditionalChinese Medicine,Shanghai,China.Our findings assessed on the basis
of biochemical  test, bone  mineral density  and histomorphometric  parameters show  that aqueous extract of
Epimedii sagittatum has a definite antiosteoporotic effect and can prevent the ovariectomy-induced bone loss
in rats.
In vitro studies
An in vitro study means that the evaluation was done in a lab not using any animals or humans.
Effect on cartilage
Effect of five species of Epimedium on growth of cartilage and proliferation of cartilage cell in vitro
Zhongguo Zhong Yao Za Zhi. 2006.
To observe  the  effect  of Epimedium  brevicornum  plant, E.  sagittatum, E.  koreanum, E,  wushanense and E.
elongntum on the growth of cartilage and proliferation of cartilage cell in vitro.E.brevicornum and E.sagittatum
can  improve the  growth  of cartilage and  proliferation of  cartilage  cell in  vitro.The other  three  Epimedium
species did not have the same effect.

Osteoporosis and bone health
Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts
Zhongguo Zhong Yao Za Zhi. 2008; Department of Pharmacy, Lanzhou General Hospital, PLA, Lanzhou, China.
To  investigate  the  effects  of  total  flavonoid  extract  of  Epimedium   sagittatum  on  the  proliferation and
differentiation of newborn rat calvarial osteoblasts.Flavonoids from this herb have anti-osteoporosis properties
The flavonoid icariin may be largely responsible for these benefits.

Safety

It is interesting to note that although at least 15 fifteen active compounds have been identified in epimedium
extracts,(luteolin, icariin,quercetin,and various epimedins),many supplement companies currently use alcohol
extracts standardized only for high levels of icariin.The traditional use of epimedium,however,is as a hot-water
decoction(tea),which would result in a very different profile of active constituents when compared to the high
icariin  alcohol extracts that are more  commonly used in commercial products. Although at least one test test
tube study has shown icariin to protect liver cells from damage with by various toxic compounds,other feeding
studies ( in rodents ) have  suggested that high-dose  icariin may be  associated with  kidney and  liver toxicity
There have been no reports  of adverse  side effects  associated with the traditional preparation of epimedium
(water-extracted) at the suggested dosage (250 to 1,000mg per day).

The Dosage of Horny Goat Weed Extract

Because all of the existing scientific  evidence for the anti-stress and cortisol-controlling effect of  epimedium
has been demonstrated for  water-extracted epimedium (that is, as a tea), and because this form of extraction
may result in a  safer form of epimedium ( compared to the high-icariin alcohol extract ), it may  be prudent to
select supplements that specifically use a more traditional formulation. There have been no reports of adverse
side effects associated with the traditional preparation of epimedium ( water-extract) at the suggested dosage
(250-1,000mg/day in 2-3 divided doses).

Refreence :
1.CAI An-min,WAN Hai-ying,ZHOU Hong,LI Dong (Dept.of Clinical Laboratory,Tongji Hospital,Tongji University School of
Medicine,Shanghai 200065,China);Induction of apoptosis by CDA-Ⅱ on acute promyelocytic  leukemia cells[J]; Journal
of Tongji University(Medical Science);2010-02
2.Tan Peng,Xu Juan,Zhong Lingli,Lei Haimin,Yang Lei,Li Fei ( School of Chinese  Materia  Medica,Beijing University of
Chinese Medicine,Beijing100102,China);HPLC-MS~n Analysis of Flavonoids in Epimedium wushanense T.S.Ying[J];World
Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica);2012-03
3.DU Ting-ting,CHEN Zhi ( Jinan Second People′s Hospital,Jinan 250001,China ); Research progress on icariin in Herba
Epimedii[J];Qilu Pharmaceutical Affairs;2012-09
4.SHENG Hua-gang ( College of Pharmacy, Shandong University of  Traditional Chinese Medicine, Jinan 250355,China)
Progress on Effect of Epimedii Folium on Osteoblasts and Osteoclasts[J];Food and Drug;2012-11
5.ZhouJinxing,LiShenghe,Ning Kangjian,JinGuangming (Department of Animal Science,AnHui Science and Technology
University,FengyangAnhui 233100);Effect on the Tissue Structure of Partridge Shank Chicken’s Spleen with Different
Dosage Extraction from Pilose Asiabell Root.and Herba Epimedii Brevicornus[J];Chinese Agricultural Science Bulletin;
2012-05
6.Zheng Jun, Xu Xiao-yan, Tang Wei-zhong, Zhou En-yuan, Nian Hua  Department of  Orthopedics, Yue yang Hospital
Shanghai  University of  Traditional  Chinese  Medicine,  Shang hai 200437, China; Controlled-release  icariin  loaded-hydroxyapatiteitosan scaffold for repair of bone defects;ChineseJournal of Tissue Engineering Research;2012-08
7.Li lisheng1, Liu Juan2, Wang anbing1,Chen lan1,Lu yuanfu1,Liu jie1 (1.The Key Laboratory of Basic Pharmacology of
Guizhou Province/Department of Pharmacology,Zunyi Medical College,Zu, Guizhou 563000,China;2.Affiliated Hospital
of Zunyi Medical College,Zunyi,Guizhou 563000,China);Effects of icariin on hepatic phase2 drug metabolism enzymes
and transporters in rats of different age[J];Acta Academiae Medicinae Zunyi;2012-01
8.DING Huai-li,WU Yin-sheng,LIN Yu,LIN Yan-ping.Orthopaedic and Traumatology Department, FUTCM, Fuzhou, Fujian
350108;Fujian Academy of Integrative Medicine, FUTCM, Fuzhou,Fujian 350108,China; Changes with age and effect of
Icariine on genetic expression of RANKL-OPG in Rat’s Osteoblasts[J]; The Journal of Traditional Chinese  Orthopedics
and Traumatology;2010-04
9.XIE Gao-Yu,CHEN Kai,LIU Hao-Ran,et al. Pharmacology College of Guiyang College of  Traditional  Chinese  Medicine
Guiyang 550002,Guizhou,China;Effect of Icaririn on  expression of  MMP-2  and  MMP-9 of testis  tissue in  D-galactose
induced aging rats[J];Chinese Journal of Gerontology;2012-16
10.Yin Hong, Qian Wei-qing  Department of  Orthopedics and  Traumatology, Nanjing  Hospital of  Traditional Chinese
Medicine, Third Clinical Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing 210001, Jiangsu Province
China;Calcium phosphate cement/epimedium composite materials for improving fracture healing of osteoporotic rats
[J];Chinese Journal of Tissue Engineering Research;2012-29
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