MIGU supplied Agaricus Bisporus Extract polysaccharide 10%,20%,30%,40%,50%; refined powder and OEM service with analysis meets the EP, USP, JP, CP.....
Organic Agaricus Bisporus Extract 10%, 20%, 30%, 40%, 50% polysaccharide by UV and refined powder offered by
16 years experienced cGMP manufacturer with warehosues in China–MIGU
Latin Name: Agaricus bisporus(J.E.Lange) Imbach
Material Original: ZheJiang China
Extracted Part: Fruit body
Supported Purity: Polysaccharides 10%~50% 5:1~50:1
Basic Information of Agaricus Bisporus Extract specification from MIGU Nutrition:
The History of Agaricus Bisporus Extract
Agaricus bisporus is an edible basidio mycete mushroom native to grass lands in Europe and North America
This mushroom may be known as common mushroom,button mushroom,white mushroom,cultivated
mushroom,table mushroom,and champignon mushroom.When immature and brown,this mushroom may
be known variously as Swiss brown mushroom,Roman brown mushroom,Italian brown,Italian mushroom
cremini or crimini mushroom,brown cap mushroom and white button mushroom.
Human beings have been consuming white button mushrooms since Ancient times.According to Dr
Michael Murray and Dr Joseph Pizzorno,authors of”The Encyclopedia of Healing Foods,”ancient Egyptians
believed that the Agaricus bisporus species of mushrooms held the key to immortality,while Ancient
Romans revered the mushroom as one of the foods of the gods.During the 1600s,the French began to
cultivate Agaricus bisporus,using dark underground tunnels beneath Paris that are used for mushroom
growing today.Cultivation of mushrooms began in the United States during the 1800s.
Agaricus blazei is a medicinal mushroom that contains a special class of polysaccharides known as beta
glucans.Studies show beta glucan stimulates activity of natural killer cells,which are an important part of
the immune system.The agaricus in this product is extracted with the preferred hot water/alcohol
method to increase its digestibility&enhance bioavailability of the polysaccharides.Originally discovered
in Brazil,it is widely consumed in many countries,where it’s regarded as a health food due to its medicinal
properties.Below are our Agaricus Bisporus Extract specification purity supported:
Agaricus Bisporus Extract Mushroom Origin–Cultivated!!!
The earliest description of the commercial cultivation of A.bisporus was made by French botanist Joseph
Pitton de Tournefortin 1707.French agriculturist Olivier de Serres noted that transplanting mushroom
mycelia would lead to more mushrooms.
Originally,cultivation was unreliable as mushroom growers would watch for good flushes of mushrooms in
fields before digging up the mycelium and replanting them in beds of composted manure or inoculating
‘bricks’of compressed litter,and manure.Spawn collected this way contained pathogens and crops
commonly would be infected,or not grow at all.In 1893,sterilized,or pure culture,spawn was discovered
and produced by the in Paris,for cultivation on composted horse manure.
Today’s commercial variety of the common mushroom originally was light brown color.In1926, Pennsylvania
mushroom farmer found a clump of common mushrooms with white caps in his mushroom bed.As with the
reception of white bread,it was seen as a more attractive food item and became very popular.Similar to
the commercial development history of the navel organge and Red Delicious apple,cultures were grown
from the mutant individuals,and most of the creamcolored store mushrooms marketed today are products
of this 1926 chance natural mutation.
Now in China,we owned GAP planted base for Agaricus Bisporus to get the Dung grass saprophytic bacteria
In a 100 gram serving,raw white mushrooms provide 22 calories and are an excellent source(>19%of the
Daily Value .DV)of the B vitamins riboflavin niacin and pantothenic acid (table).Fresh mushrooms are also
a good source(10-19%DV)of the dietary mineral , phosphorus (table).While fresh A.bisporus only contains 0.2
micrograms(8 IU)of vitamin D as ergocalciferol (vitamin D2),the ergocalciferol content increase substantially
after exposure to UV light
Agaricus Bisporus Extract benifits
A Heart Health Benefits
Heart disease is a leading cause of death throughout the world,but consuming button mushrooms can keep
you from becoming another statistic.A major risk factor for heart disease is atherogenesis,which is the
formation of plaque on arterial walls,which causes atherosclerosis and hardening of the arteries.Researchers
at Arizona State University tested the effects of button mushrooms on the human endothelial cells in a test
tube.The results of their study,published in the July 2010 issue of”Nutrition Journal,”show that button
mushrooms reduce inflammation in arterial cells and prevent white blood cells from sticking to arterial walls
The researchers conclude that consuming button mushrooms may be a means to prevent heart disease.
B Immune System Benefits
Specific cell in the body,referred to as natural killer cells,respond rapidly to foreign invaders such as viruses
or cancer cells.Their rapid response is crucial to the immune system,as it helps the body fight disease.The
June 2007 issue of the”Journal of Nutrition”reports that eating button mushrooms can boost the immune
system by increasing the activity of natural killer cells.Although they do not fully understand how,scientists
believe that it’s the polysaccharide content of the mushrooms that is responsible for their immune-boosting
C Anticancer Benefits
Button mushrooms protect the body from various cancer cell lines.In June 2010,the department of plant
pathology at Penn State released a report stating that button mushrooms have been found effective at
treating breast,colon and prostate cancers.According to a study in the December 2006 issue of”Cancer
Research”eating one1/2cup of button mushrooms a day can stop the growth of breast cancer tumors.healthy
woman may eat less than 1/2 cup to greatly reduce the risk of developing breast cancer.
D Nutritional Benefits
Button mushrooms contribute to the recommended daily intake of several vitamins and minerals.The USDA
reports that mushrooms contain high amounts of copper,which is needed to produce blood cells&maintain
heart health.Additional nutrients are vitamins C,D and B;and the minerals selenium,iron,magnesium
phosphorous,potassium and zinc.When cooked,most of the nutrient content of mushrooms remains the
same,while some nutrients lose between 5 and 20 percent of their value.
E Diabetes and blood sugar benefit
The mushroom Agaricus Blazei in combination with metformin and gliclazide improves insulin resistance in
type 2 diabetes:a randomized,double-blinded,and placebo-controlled clinical trial.JAlternative Complement
Med.2007.Of a population of 536 registered diabetes patients with72 subjects(1)aged between20 and75years
(2)being Chinese,(3)having type 2 diabetes for more than 1 year,and(4)having been taking gliclazide and
metformin for more than 6 month were enrolled in this study.The enrolled patients were randomly assigned
to either receiving supplement of Agaricus blazei extract or placebo(cellulose)1500 mg daily for12 weeks
The mushroom extract improves insulin resistance among subjects with type 2 diabetes.The increase in
adiponectin concentration might be the mechanism that brings the beneficial effect.
Agaricus Bisporus Extract side effects,risk,safety,toxicity
Up to 2014,few agaricus side effects had been reported in Japan,where it has been in use as a dietary
supplement since the mid 1990s.There is now a report in the medical literature that three cancer patients
taking an agaricus supplement had liver damage.An Alternative Medicine,Agaricus blazei,May Have Induced
Severe Hepatic Dysfunction in Cancer Patients.Japan J Clinical Oncology.2006..
We report three case of patient with advanced cancer who showed severe hepatic damage,and two of whom
died of fulminant hepatitis.All the patients were taking Agaricus blazei extract,one of the most popular
complementary and alternative medicines among Japanese cancer patients.In one patient,liver functions
recovered gradually after she stopped taking it,but she restarted taking it,which resulted in deterioration of
the liver function again.The other patients who were admitted for severe liver damage had started taking it
several day before admission.Although several other factor cannot be completely ruled out as the causes of
liver damage,strong causal relationship between the Agaricus blazei extract and liver damage was suggested
and,at least,taking Agaricu blazei extract made the clinical decision-making process much more complicated
Comments by Dr.Sahelian:For the time being,limit your intake to maximum 3 times a week and a full week
off each month.It is not clear at this time whether the problem was with the particular agaricus supplement
these patient were using,i.e,Himematsutake as it is called in Japan,or whether the problem of liver harm
applies to all brands.
Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F 344 rats.Food Chem Toxicol.
2005 As a part of its safety assessment,the present 90-day subchronic toxicity study was performed in F344
rats.In conclusion,A.blazei Murrill extract even at 5%in the diet did not cause remarkable adverse effects in
1)USDA: White Button Mushroom
2)”Nutrition Journal”; Both Common and Specialty Mushrooms Inhibit Adhesion Molecule Expression and In Vitro Binding of
Monocytes to Human Aortic Endothelial Cells; KR Martin; Jul. 16, 2010.
3)”Journal of Nutrition”; Dietary Supplementation with White Button Mushroom Enhances Natural Killer Cell Activity; Wu
Dayong, et al.; June 2007.
4)Department of Plant Pathology at Penn State; The Anti- cancer Activity of Agaricus Bisporus Against Human Cancers;
Tongtong Wu; June 12, 2010.
5)”Cancer Research”;Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms(Agaricus bisporus);ShiuanChen
et al.; Dec. 15, 2006.
6)USDA: Nutrient Data on Mushrooms Updated
7) Spencer DM. (1985).” The mushroom–its history and importance “.In Flegg PB, Spencer DM, Wood DA. The Biology and
Technology of the Cultivated Mushroom. New York: John Wiley and Sons. pp. 1–8. ISBN 0-471-90435-X.
8)Genders 1969, p. 19
9)Genders 1969, p. 18
10)Genders 1969, p. 121
11)Chang ST. (1993). “Mushroom biology:the impact on mushroom production and mushroom products”.In Chiu S-W,Buswell
J, Chang S-T. Mushroom Biology and Mushroom Products.Hong Kong: Chinese University Press. pp. 3–20. ISBN 962-201-610-3